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Berlin 2024 – wissenschaftliches Programm

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CPP: Fachverband Chemische Physik und Polymerphysik

CPP 30: Charged Soft Matter, Polyelectrolytes and Ionic Liquids II

CPP 30.5: Vortrag

Mittwoch, 20. März 2024, 16:00–16:15, H 0107

Phase behavior and interactions of proteins in the presence of NaSCNMahnoush Madani1, Nele Koch1, Debes Ray2, Jan K. G. Dhont2, Kyongok Kang2, and •Florian Platten1,21HHU Düsseldorf, Faculty of Mathematics and Natural Sciences, Düsseldorf, Germany — 2FZ Jülich, IBI-4, Jülich, Germany

The state diagram of protein (lysozyme) solutions in the presence of sodium thiocyanate (NaSCN) is determined experimentally. Compared to NaCl, far lower salt concentrations are necessary to induce crystal formation and liquid-liquid phase separation (LLPS), respectively. These findings suggest a salt-specific effect of the SCN anion, strongly increasing net inter-protein attractions. Indeed, small-angle x-ray scattering experiments, used to determine the effective structure factor of the protein solutions, indicate a decrease of the second virial coefficient with SCN content, corresponding to increased net attractions.

Keywords: protein phase behavior; crystallization; LLPS; SAXS

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