Berlin 2024 – wissenschaftliches Programm
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CPP: Fachverband Chemische Physik und Polymerphysik
CPP 42: Gels, Polymer Networks and Elastomers III
CPP 42.1: Vortrag
Donnerstag, 21. März 2024, 15:00–15:15, H 0106
SAXS analysis of electrically controlled drug release hydrogels for diabetes treatment — •Yining Sun1, Clement Blanchet2, and Michael Gradzielski1 — 1Stranski-Laboratorium für Physikalische und Theoretische Chemie, Institut für Chemie, Technische Universität Berlin, Straße des 17. Juni 124, D-10623 Berlin, Germany — 2European Molecular Biology Laboratory, Hamburg Outstation, Notkestrasse 85, 22603 Hamburg, Germany
Herein, we present the fabrication of conductive hydrogels that were prepared using quaternized chitosan grafted with polyaniline (QCSPA), polyvinyl alcohol, and boronic acid. This hydrogel was dynamically crosslinked by boronate esters between alcohol and boronic acid and ionic interactions between chitosan and boronic acid. The modified QCSPA endows the good bulk conductivity of the hydrogel. We studied the crosslinking of this hydrogel by rheology and small angle scattering (SAXS and SANS), especially the effect of the QCSPA content. Besides, the passive diffusion and electro-triggered insulin release behavior are also studied by SAXS, to observe the relations between hydrogel structure and insulin release kinetics. The obtained results underline the importance of mesh size in the release procedure, which can be designed by varying hydrogel components. The resulting hydrogel demonstrates electrically triggered insulin release, aiming at localized and on-demand therapeutic delivery. The system shows high current tolerance, high drug loading capacity, and is effective in vitro drug release, which suggests a new method to advance diabetes treatment.
Keywords: Hydrogel; Drug release; SAXS