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DY: Fachverband Dynamik und Statistische Physik
DY 10: Nonlinear Dynamics, Synchronization and Chaos
DY 10.10: Vortrag
Montag, 18. März 2024, 17:30–17:45, BH-N 128
Toward Better Defibrillation through Genetic Optimisation — •Marcel Aron1,2,3,4, Ulrich Parlitz1,3,4, and Stefan Luther2,1,3,4 — 1Max Planck Institute for Dynamics and Self-Organization, Göttingen, Germany — 2Institute of Pharmacology and Toxicology, University Medical Center Göttingen, Germany — 3Institute for the Dynamics of Complex Systems, Georg-August-Universität Göttingen, Germany — 4German Center for Cardiovascular Research (DZHK e.V., partner site Niedersachsen), Göttingen, Germany
Cardiac fibrillation results in the lethal, chaotic disruption of the heart’s electricity-coordinated contraction mechanism. Its current standard treatment, defibrillation, may damage tissue and even lead to (e.g.) elevated fibrillation susceptibility long-term. This has motivated research into alternative, less intrusive (i.e. low-energy) defibrillation schemes beyond the usual singular, potent shock.
The search for better defibrillation schemes has proven difficult largely due to the sheer amount of possible shock sequences to consider. We sought to reduce the number of candidate low-energy shock sequences through the design and application of an optimisation heuristic inspired by evolutionary biology. To guide this heuristic, we consulted simplified defibrillation simulations.
This talk covers our quantification of "better" in the context of defibrillation schemes and an outline of our optimisation heuristic. We also show our findings in its application to optimising multi-shock defibrillation, including the discovery of a potentially global optimum.
Keywords: cardiac electrophysiology; reaction-diffusion systems; genetic optimisation; nonlinear dynamics; chaos