Berlin 2024 – wissenschaftliches Programm

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DY: Fachverband Dynamik und Statistische Physik

DY 10: Nonlinear Dynamics, Synchronization and Chaos

DY 10.8: Vortrag

Montag, 18. März 2024, 17:00–17:15, BH-N 128

Chaos Control in Cardiac Dynamics: A novel approach to low-energy defibrillation — •Daniel Suth and Thomas Lilienkamp — Computational Physics for Life Science, Nuremberg Institute of Technology Georg Simon Ohm, Nuremberg, Germany

Various dynamical systems exhibit chaotic states with spiral wave-like patterns. Control schemes for chaotic patterns aim to terminate or synchronize such states, by applying a single or multiple stimuli to the system. One possible application is the use of multiple low-energy pulses to terminate ventricular and atrial fibrillation, with the advantage of avoiding negative side effects associated with singular high-energy defibrillation shocks.

This study demonstrates that sequences of well-timed stimuli provide high success rates at low amplitudes to terminate chaotic dynamics in numerical simulations of cardiac tissue. Therefore, we propose a simple and robust approach to calculate the pulse timings derived directly from simple characteristic features of the associated state variables.

We demonstrate this method using numerical simulations with four different 2D computational models of cardiac dynamics that vary in complexity and target species. Therefore, a detailed statistical analysis of the proposed approach, the results that can be achieved with it and a comparison with multiple existing methods is provided.

Furthermore, we investigate fundamental mechanisms of cardiac dynamic models that can be utilised to terminate chaotic states in such systems.

Keywords: Defibrillation; Arrhythmias; Chaos control; Excitable media