Berlin 2024 – wissenschaftliches Programm
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DY: Fachverband Dynamik und Statistische Physik
DY 10: Nonlinear Dynamics, Synchronization and Chaos
DY 10.9: Vortrag
Montag, 18. März 2024, 17:15–17:30, BH-N 128
Pulse Optimization for Activation of Virtual Electrodes — •Justine Wolter1,2, Ulrich Parlitz1,2, and Stefan Luther1,2,3 — 1MPI for Dynamics and Self-Organization, Göttingen — 2University Medical Center, Göttingen — 3Deutsches Zentrum für Herz-Kreislauf-Forschung, Partner Site Niedersachsen, Göttingen, Germany
Cardiac arrhythmias represent one of the major causes of mortality worldwide. In case of cardiac arrhythmias, the normal heart beat is disturbed, affecting the heart's pumping function. Life-threatening cases such as ventricular fibrillation are commonly treated with a single high-energetic shock that causes traumatic pain, tissue damage and a worsening prognosis. Low-energy defibrillation techniques that apply a sequence of weak electrical pulses reduce the necessary energy while still being able to control the fibrillation. These methods use virtual electrodes which consist of heterogeneities in cardiac tissue acting as wave emitters in the presence of an external electrical field.
In this study, we present numerical simulations of two dimensional excitable media in a mono- and a bidomain model, showing the impact and dynamics of such virtual electrodes.
For different sizes of heterogeneities we find that by optimizing the pulse duration and form, the necessary energy for activation is significantly reduced. With our work, defibrillation protocols that apply sequences of weak, energetic electrical pulses can be further optimized. Therefore, we provide valuable insights for the further development of improved defibrillation techniques.
Keywords: Cardiac systems; Reaction-Diffusion Systems; Excitable Media