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DY: Fachverband Dynamik und Statistische Physik

DY 37: Statistical Physics of Biological Systems II (joint session BP/DY)

DY 37.6: Vortrag

Donnerstag, 21. März 2024, 11:00–11:15, H 1028

Trajectory mutual information in biochemical systems: Gaussian vs. Poissonian fluctuations — •Anne-Lena Moor^1,2, Christoph Zechner^1,2, and Pieter Rein ten Wolde³ — ¹Max Planck Institute of Molecular Cell Biology and Genetics — ²Center for Systems Biology Dresden — ³AMOLF Amsterdam

Signal processing in biochemical networks relies on dynamic information transmission between time-trajectories of the respective molecular components. From a mathematical point of view, the transferred information can be described via the mutual information. Traditionally, this has been calculated using a Gaussian approximation. Our recent work suggests that this method is not always suitable for every biochemical networks which can lead to quantitative and qualitative mismatches to the exact solution. In this work, we explain the origin of these discrepancies and present a modified version of the Gaussian framework that aligns better with the characteristics of stochastic biochemical networks.

Keywords: mutual information; information transfer; reaction networks; Gaussian approximations