Berlin 2024 – wissenschaftliches Programm
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DY: Fachverband Dynamik und Statistische Physik
DY 59: Brownian Motion and Anomalous Diffusion
DY 59.7: Vortrag
Freitag, 22. März 2024, 11:00–11:15, BH-N 334
Density fluctuation analysis of biological matter — •Conrad Möckel1,2,3, Abin Biswas1,2,4, Simone Reber4, Vasily Zaburdaev2,3, and Jochen Guck1,2,3 — 1Max Planck Institute for the Science of Light, 91058 Erlangen, Germany — 2Max Planck Zentrum für Physik und Medizin, 91058 Erlangen, Germany — 3Friedrich Alexander Universität Erlangen-Nürnberg, 91058 Erlangen, Germany — 4Max Planck Institute for Infection Biology, 10117 Berlin, Germany
The characterization of the dynamical properties of biological matter plays an important role in unraveling its complexity and associated functions. Here we employ differential dynamic microscopy in combination with bright field microscopy to probe and evaluate the inherent density fluctuations at present in the sample under study. Using theoretical models, this approach allows for quantification of the time and length scale dependent viscoelastic properties of optically transparent systems as demonstrated for high speed supernatant (HSS) Xenopus laevis egg extract. We find that upon microtubule formation, the HSS exhibits subdiffusive characteristics at two distinct time scales which can be connected to dynamical caging and escape events. Our findings illustrate the relevance of this methodology for characterizing dynamical heterogeneities of cytoplasm non-invasively, beyond multiple particle tracking.
Keywords: Microrheology; Differential Dynamic Microscopy; Fractional Brownian Motion; Dynamic Caging