Berlin 2024 – scientific programme

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MA: Fachverband Magnetismus

MA 46: Poster II

MA 46.30: Poster

Thursday, March 21, 2024, 15:00–18:00, Poster C

Characterizing the defocusing behaviour of magnetic microparticles for the application in three-dimensional trajectory tracking — •Nikolai Weidt, Yahya Shubbak, Rico Huhnstock, and Arno Ehresmann — Department of Physics and Center for Interdisciplinary Nanostructure Science and Technology (CINSaT), University of Kassel, Heinrich-Plett-Str. 40, D-34132 Kassel

To realise Lab-on-a-chip systems superparamagnetic particles (SPPs) can be surface-functionalized to bind specific analytes [1]. The directed transport of SPPs above magnetically stripe-patterned exchange bias layer systems is a promising approach to achieving analyte binding and transfer [2]. Precise analysis of three-dimensional SPP trajectories in this system can lead to the detection of analyte-binding events. To access the third dimension, the defocusing of particles moving out of the microscope’s focal plane during transport steps is measured [3]. In this work, the quantization of defocusing is done by determining the Tenenbaum gradient (TG) of single particles. Using a calibration procedure, the z-coordinate of SPPs is derived from the measured TG. The obtained 3D trajectories are confirmed by numerical simulations for SPP motion. [1] Rampini, S., Li, P., Lee, G.U., 2016. Lab on a Chip 16, 3645*3663. [2] D. Holzinger, I. Koch, S. Burgard, and A.Ehresmann, ACS Nano 9, 7323 (2015) [3] Huhnstock, R., Reginka, M., Sonntag, C., Merkel, M., Dingel, K., Sick, B., Vogel, M., Ehresmann, A., Sci Rep 12, 20890.

Keywords: particle transport; simulation; 3D