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MA: Fachverband Magnetismus

MA 51: Caloric Effects in Ferromagnetic Materials

MA 51.3: Vortrag

Freitag, 22. März 2024, 10:15–10:30, H 2013

A temperature model for the Magnetic Hyperthermia — •Viorica Monica Moisiuc and Iordana Astefanoaei — Faculty of Physics, Alexandru Ioan Cuza University of Iasi, Romania

Magnetic hyperthermia is an important medical technique which uses therapeutic heat from the magnetic nanoparticles when an external high frequency magnetic field was applied. The temperature developed within tumoral tissues by the nanoparticles can be controlled by the fine control of the magnetic field parameters: i) frequency and ii) the amplitude of the field. In the last years, this topic receives a special attention in all theoretical and experimental studies. The spatial distribution of magnetic nanoparticles in the tumoral tissue significantly influences the temperature during this treatment. In this work, a concentric tissue geometry (tumoral tissue surrounded by the healthy tissue) was considered. The magnetic nanoparticles with different properties are distributed non-uniformly in the tumor tissue. The thermal response of the tumoral tissue heated by the magnetic nanoparticles in a high-frequency electromagnetic field was analyzed by the analytical and numerical computations. Bioheat transfer equation was solved to obtain the temperature field within tissues. The spatio-temporal evolution of the temperature in correlation with the nanoparticles volume fraction was analyzed for different types of magnetic particles injected into the tumor tissue. The mathematical model allows the computation of the hyperthermic temperature for nanoparticle systems with the following particularities: different concentrations, sizes and magnetic and thermal properties (maghemite, magnetite).

Keywords: magnetic hyperthermia; magnetic nanoparticles; hyperthermic temperature