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MA: Fachverband Magnetismus

MA 7: Bulk Magnetic Materials and Magnetic Particles/Clusters

MA 7.12: Talk

Monday, March 18, 2024, 12:30–12:45, EB 407

Frequency mixing magnetic detection for characterization of SPIONs — •Ali Mohammad Pourshahidi, Andreas Offenhäusser, and Hans-Joachim Krause — Institute of Biological Information Processing, Bioelectronics (IBI-3), Forschungszentrum Jülich, Germany

The research on superparamagnetic iron oxide nanoparticles (SPIONs) explores their magnetic properties for bio-sensing and diagnostics. Frequency Mixing Magnetic Detection (FMMD) exploits SPIONs’ nonlinear magnetization under dual-frequency magnetic excitation fields (a low-frequency field f₂ and a high-frequency field f₁). As a result, mixing harmonics in form of f₁ + n · f₂ are generated that reveal insights into SPION behavior [1]. FMMD has shown significant potential in bio-sensing for point-of-care monitoring, offering a portable and a handheld solution [2]. Integration of a static offset magnetic field enables the detection of both even and odd harmonics. This enhancement broadens the diagnostic applications to include multiplex detection and characterization of SPION core size [3,4]. These advancements underscore FMMD’s role as a tool, for better understanding of magnetic nanoparticle behavior, which is vital for advancing magnetic bio-sensing technologies. This presentation aims to highlight FMMD’s applications in multiplex detection and core size analysis of SPIONs.

1. H.-J. Krause et al. JMMM 311( 2007) 436 2. S. Achtsnicht et al. PLOS ONE 14 (2019) e0219356 3. A. M. Pourshahidi et al. Sensors 21( 2021) 5859 4. A. M. Pourshahidi et al., JMMM 563 (2022) 169969

Keywords: Frequency mixing magnetic detection; Magnetic nanoparticle; Magnetic biosensing; Magnetic nanoparticle core size determination; Multiplex detection