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MA: Fachverband Magnetismus
MA 8: INNOMAG e.V. Prizes 2024 (Diplom-/Master and Ph.D. Thesis)
MA 8.3: Talk
Monday, March 18, 2024, 15:40–16:00, H 1058
Optimized hyperthermia approach using Fe3O4/SiO2/Ni multishell nanoellipsoids — •Inci Nur Sahin1, Marina Spasova1, Michael Farle1, Veronica Salgueirino2, and Ecem Tiryaki2 — 1University Duisburg-Essen, Duisburg, Germany — 2University of Vigo, Vigo, Spain
The use of approximately 20nm magnetite nanoparticles (NPs) for inductive heating has proven effective in cancer treatment, inducing necrotic cell death at temperatures above 43°C. Operating in the superparamagnetic state, these NPs don't exhibit remanent magnetization and stray fields, averting agglomeration and potential blood vessel clogging. Since foreign bodies below 50nm are deposited in the kidneys instead of in the tumour, larger diameters are desirable. However, magnetite particles that exceed the 20nm limit enter the ferromagnetic state with a noticeable demagnetizing field. This inevitably leads to the formation of clusters and poses a risk to the blood vessels. For this reason, magnetite/silica/nickel multi-shell ellipsoids were produced with the aim of compensating the stray fields of ferromagnetic NP. This is to be achieved by extinguishing the stray field of the core and the outer shells. Through a wet chemical process, 545nm long and 165nm wide Fe3O4/SiO2 NPs with a 10% standard deviation were prepared and coated with a 50nm thick nickel shell. Comparing the Nickel-sheathed and non-Nickel-sheathed NPs, it was found that the Nickel-sheathed NPs indeed exhibited a reduced remanence, provided three times the heating power 180 W/g during induction heating, and provided seven times the temperature increase ΔT= 20°C.
Keywords: Hyperthermia; Multi-Shell Ellipsoids; Cancer Treatment; Magnetic Nanoparticles