Berlin 2024 – wissenschaftliches Programm

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ST: Fachverband Strahlen- und Medizinphysik

ST 5: Poster Session

ST 5.2: Poster

Mittwoch, 20. März 2024, 11:00–12:30, Poster A

Advanced nano-CT with laboratory X-ray radiation: optimization of geometry and anode material — •Claas Warnecke, Paul Meyer, Jordi Carstens, and Tim Salditt — Institute for X-ray physics, University of Göttingen, Germany

Phase-contrast tomography of biological tissue with laboratory X-ray sources is a quickly advancing imaging modality which opens up new possibilities for three-dimensional virtual histology and clinical pathohistology, to be performed in hospitals rather than at synchrotron sources.

In this work, a 3D virtual histology setup is realized using a nanofocus X-ray tube with a cone-beam geometry, as well as scintillation and direct photon-counting detectors. The focus of this work is the optimization of the experimental parameters of the setup including focal spot size and photon flux, magnification and phase contrast. The X-ray tube also allows for an easy exchange of anodes that makes a quantitative comparison between different anode materials possible, including tungsten, copper and molybdenum. The results are compared to data from a synchrotron source.

Keywords: Phase-contrast computed tomography; Virtual histology; Laboratory X-ray source