Berlin 2024 – scientific programme

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ST: Fachverband Strahlen- und Medizinphysik

ST 5: Poster Session

ST 5.5: Poster

Wednesday, March 20, 2024, 11:00–12:30, Poster A

Cell Irradiation Experiments and Film Dosimetry with Low Energy Electrons from a Compact Ultrafast Electron Source — •Julian Freier¹, Bastian Löhrl¹, Leon Brückner¹, Christoph Bert², Luitpold Distel³, and Peter Hommelhoff¹ — ¹Department Physik, FAU Erlangen-Nürnberg — ²Department Medizinische Strahlenphysik, Universitätsklinikum Erlangen, FAU — ³Department Strahlenbiologie, Universitätsklinikum Erlangen, FAU

Millimeter-sized accelerators could provide new opportunities for radiotherapy [1]. Such a chip-based (electron) accelerator using nanophotonic structures driven by femtosecond laser pulses could be built into an endoscopic system and be used for highly localized cancer treatment, for example. Motivated by this goal, we present the successful implementation of a cell irradiation experiment using pulsed 40 keV electrons, which coincides with the latest electron energy achieved in an accelerator on a chip [2]. The femtosecond laser-triggered compact electron source can provide currents of few fA on the sample position. Irradiation-induced DNA double strand break damages are detected and visualized in different types of cells through gH2AX immunofluorescence staining. Furthermore, the first signs of high radiation severity have been shown with colony formation assay and damage after long repair times. For dosimetry, unlaminated EBT3 GafChromic films are investigated on their response and efficiency to low energy electron radiation and are compared with X-Ray radiation. [1]*England, et al. "Dielectric laser accelerators." RMP 86, 1337 [2]*Chlouba, et al. Nature 622, 476 (2023).

Keywords: Dielectric Laser Acceleration; Low energy electron irradiation; Dosimetry; EBT3 GafChromic radiochromic film