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ST: Fachverband Strahlen- und Medizinphysik
ST 8: Accelerators for Medical Applications (joint session ST/AKBP)
ST 8.4: Vortrag
Donnerstag, 21. März 2024, 10:15–10:30, PC 203
Investigation of Measurement Techniques to Determine the Applied Dose of Ultra-High Energy Electron Beams in Cell Samples for FLASH Therapy at ELSA — •Leonardo Thome1, Manuela Denz2, Klaus Desch1, Stephan Garbe2, Frank Giordano3, Kelly Grunwald1, Carsten Herskind3, Miriam Lösgen1, Dennis Proft1, and Susanne Spaeth2 — 1Physikalisches Institut der Universität Bonn — 2Klinik für Strahlenthearpie und Radioonkologie der Universitätsklinik Bonn — 3Klinik für Strahlentherapie und Radioonkologie der Universitätsklinik Mannheim
Ultra-high energy electrons (UHEE) are used to investigate their effect on tumor cells and healthy tissue in short pulses of microseconds at the electron accelerator facility ELSA. This may enable highly efficient treatment of deep-seated tumors due to the FLASH effect. In a preliminary setting the booster synchrotron is used to deliver electrons of 1.2 GeV energy to irradiate cell samples placed in a water phantom. Irradiation occurs with dose rates of up to 10 MGy/s due to the short pulse lengths of 250 ns. A precise dose determination is necessary to monitor the efficacy of the biological effect. Measurement techniques based on the usage of different detector types, such as radiochromic films, luminous screens, ionisation chambers and a diamond based detector, are evaluated.
Keywords: Dosimetry; Radiation therapy