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MS: Fachverband Massenspektrometrie

MS 4: Poster

MS 4.11: Poster

Dienstag, 12. März 2024, 17:00–19:00, Aula Foyer

Characterization of ion transmission in an electrospray ionization-mass spectrometry interface equipped with an S-lens — •Yihui Yan, Kevin Li, and Jozef Lengyel — Chair of Physical Chemistry, TUM School of Natural Sciences, Technical University of Munich, Garching, Germany

We present the design and performance of an in-house-built electrospray ionization-mass spectrometry (ESI-MS) interface equipped with an S-lens ion guide. The ion source was designed specifically for our ion beam experiments to investigate the particle nucleation and chemical reactivity of the clusters and nanoparticles. This interface consists of standard ESI-MS components, including: ion transfer capillary, the S-lens, quadrupole, and hexapole ion guides. A custom design enables systematic optimization of all relevant factors influencing transfer through the interface. Each of these ion guides was characterized over a wide range of RF frequencies and amplitudes. To track the ion transmission properties, we monitored both ion current and ion signals recorded by TOF mass spectrometer. The maximum transmission efficiency of the ESI-MS interface ranged from 10% to 30%, depending on whether the analyte was a molecular ion or a fragile cluster. Herein, we will describe the factors influencing ion transmission and analyze the observed trends.

Keywords: Nanoelectrospray; RF-only ion guides; Ion transfer; Stacked ring ion guide