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Q: Fachverband Quantenoptik und Photonik
Q 55: Poster VI
Q 55.42: Poster
Donnerstag, 14. März 2024, 17:00–19:00, Tent B
Metal-enhanced photosensitization in riboflavin functionalized gold nanoparticles: photophysical mechanisms and application in bioimaging — •Jelena Pajovic1, Radovan Dojcilovic2, Dragana Tosic2, Matthieu Refregiers3, Dusan Bozanic2, and Vladimir Vladimir2 — 1Faculty of Physics, University of Belgrade, Belgrade, Serbia — 2Vinca Institute of Nuclear Sciences - National Institute of the Republic of Serbia, University of Belgrade, Belgrade, Serbia — 3Centre de Biophysique Moleculaire, Orleans, France
Photodynamic therapy relies on the photogeneration of reactive oxygen species in complex environments by photosensitizing (PS) molecules. However, challenges persist in enhancing the PS processes while decreasing the concentration of the agents employed. This study explores the integration of PS biomolecules onto plasmonic nanoplatforms to increase their efficiency. Specifically, we report on the influence of gold nanoparticles on the PS activity of riboflavin molecules. The physical characterization of riboflavin-functionalized gold nanoparticles was conducted to better understand their electronic interactions that lead to enhanced singlet oxygen generation. The effects of the functionalized nanoparticles on live bacteria and hepatocellular carcinoma cells were investigated by fluorescence bioimaging. Preliminary findings indicate higher cell death rates in both organism systems, suggesting the nanoparticles' potential as efficient PS agents.
Keywords: photosensitization; metal nanoparticles; vitamins; fluorescence imaging; reactive oxygen species