Bonn 2025 – wissenschaftliches Programm

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MO: Fachverband Molekülphysik

MO 20: Poster – Molecular Spectroscopy and Dynamics

MO 20.13: Poster

Mittwoch, 12. März 2025, 17:00–19:00, Tent

Photofragmentation studies of cold deoxyadenosine monophosphate (dAMP) anions — •Miriam Westermeier, Christian Sprenger, Samuel White, Eric Endres, and Roland Wester — Institut für Ionenphysik und Angewandte Physik, Universität Innsbruck, Technikerstraße 25, 6020 Innsbruck, Austria

dAMP is a nucleotide which makes up one part of the DNA. It is likely involved in the mutation of genes, if the dAMP is wrongly incorporated into the DNA. Such a mutation could occur when a G to T (guanine to thymine) transversion happens. [1] dAMP consists of a sugar group, a phosphate group and the nucleobase adenine. The phosphate and the sugar form the phosphate-sugar-backbone of a DNA strand. The adenine in this case can form a hydrogen bond with a nucleobase of the second strand. It is possible to fragment the dAMP with ultraviolet light, but the absolute cross-section of this interaction is still unknown. Also the dependence of the fragment branching ratio on the dissociation wavelength is of interest. With our setup, consisting of an electrospray ionization source, an octuple, a quadrupole coupled to a cryogenic 16-pole wire ion-trap and a time-of-flight mass spectrometer, we are studying the absolute cross section of the photofragmentation, and carry out a wavelength scan as well as study the dependence of the fragment yield on the wavelength.

[1] Piette J., Biological consequences associated with DNA oxidation mediated by singlet oxygen. J. Photochem. Photobiol. B, 11, 241 (1991)

Keywords: Electro-spray ionization; dAMP; 16-pole ion trap; Photofragmentation