Göttingen 2025 – wissenschaftliches Programm
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AKBP: Arbeitskreis Beschleunigerphysik
AKBP 6: Accelerators for Medical Applications (joint session ST/AKBP)
AKBP 6.5: Vortrag
Mittwoch, 2. April 2025, 15:00–15:15, ZHG009
First Results from Cell Irradiation Experiments with Ultrahigh-Energy Electrons (UHEE) at ELSA — •Susanne Spaeth1, Manuela Denz2, Klaus Desch1, Stephan Garbe2, Frank Giordano3, Barbara Link3, Carsten Herskind3, Barbara Link3, Dennis Proft1, and Leonardo Thome1 — 1Physikalisches Insitut der Universität Bonn — 2Klinik für Strahlentherapie und Radioonkologie, Universitätsklinikum Bonn — 3Klinik für Strahlentherapie und Radioonkologie, Universitätsklinikum Mannheim
A new approach to improve radiotherapy is the use of the so-called FLASH effect, a phenomenon characterised by significantly reduced toxicity in healthy tissue at high dose rates (>40 Gy/s). This effect potentially broadens the therapeutic window, improving tumour control while minimising side effects. At the electron accelerator facility ELSA, the FLASH@ELSA project utilises ultra-high energy electrons (UHEE) to study their effect on tumour cells. Electrons with energies of 1.2 GeV are delivered in sub-microsecond pulses via the booster synchrotron, enabling dose rates up to 10 MGy/s due to the short pulse lengths of 250 ns. Cell samples are irradiated within a water phantom, with dosimetry performed using radiochromic films and luminous screens. Further the FLASH irradiation at ELSA is compared to conventional radiotherapy using a medical linear accelerator (Varian TrueBeam STx) at the University Hospital Bonn. This comparison provides the first survival curves contrasting FLASH and conventional irradiation.
Keywords: FLASH; Radiotherapy; Electron Beams