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HK: Fachverband Physik der Hadronen und Kerne
HK 4: Instrumentation I
HK 4.5: Vortrag
Montag, 10. März 2025, 16:15–16:30, SR Exp1A Chemie
Quasi-real-time range monitoring using positron-emitting therapy beams — •Sivaji Purushothaman for the Super-FRS Experiment collaboration — GSI Helmholtzzentrum für Schwerionenforschung GmbH
Therapeutic ion beams of positron emitters enable advanced cancer treatments by combining precise dose delivery with quasi-real-time range monitoring. Accurate range determination is critical to enhance treatment efficacy and protect healthy tissue. An experimental study at the FRS fragment separator of GSI Helmholtzzentrum investigated positron annihilation activity profiles during the implantation of positron-emitting oxygen and carbon beams into a PMMA phantom. This study compares 10C, 11C, 14O, and 15O isotopes for quasi-real-time range monitoring. A figure of merit was developed to assess the trade-offs between half-life, beam intensity, and measurement time. Shorter half-lives allow fewer implanted ions for accurate peak determination (e.g., 10C vs. 11C), but lower production cross-sections complicate their use. With a cross-section similar to 11C but a 10-fold shorter half-life, 15O offers quicker, more precise peak localisation with fewer ions. The study also highlights the effectiveness of in-flight production for generating therapeutic-quality ion beams.
Keywords: Quasi-real-time range monitoring; Positron emitters; Hadron therapy; Positron Emission Tomography (PET)