Bereiche | Tage | Auswahl | Suche | Aktualisierungen | Downloads | Hilfe
BP: Fachverband Biologische Physik
BP 12: Biomaterials, Biopolymers and Bioinspired Functional Materials III (joint session CPP/BP)
BP 12.6: Vortrag
Dienstag, 18. März 2025, 11:00–11:15, H46
What makes a polysaccharide biomaterial a good candidate for tissue engineering applications? — •Emma Bobu Cimpoi1, Codrut Costinas1, Emilia Licarete2, Tamás Gyulavári3, Klara Magyari4, and Monica Baia4,5 — 1Doctoral School of Physics, Babes-Bolyai University, Cluj-Napoca, Romania — 2Centre for Systems Biology, Biodiversity and Bioresources "3B", Cluj-Napoca, Romania — 3Department of Applied and Environmental Chemistry, University of Szeged, Hungary — 4INSPIRE Research Platform, Babes Bolyai University, Cluj-Napoca, Romania — 5Faculty of Physics, Babes-Bolyai University, Cluj-Napoca, Romania
Biomaterials are inovative systems used to solve medical issues. Daily, injuries produce major bleeding that affects people and, without proper care, leads to other health problems. Traditional care methods are limited and outdated, so the focus is on natural materials with hemostatic properties, that are biocompatible and non-toxic. The aim of this work was to develop biomaterials based on pullulan, alginate and gelatin in various combinations, which could stop the bleeding and regenerate the wound. The developed sponge-like materials were characterized by FT-IR spectroscopy and X-ray diffraction. Then they were evaluated in vitro in terms of porosity, toxicity, swelling and charge on the surface, using SEM, cell viability assays, water up-take and mechanical tests. The investigations revealed good results as the synthesis was succesfull, the samples swell a lot, have good shape memory properties, are porous and non-toxic. These indicate their potential to stop bleeding, and therefore further in vivo tests will be carried out.
Keywords: polysaccharides; biomaterials; hemostasis; porosity