Bereiche | Tage | Auswahl | Suche | Aktualisierungen | Downloads | Hilfe

BP: Fachverband Biologische Physik

BP 14: Poster Session I

BP 14.11: Poster

Dienstag, 18. März 2025, 10:00–12:30, P3

Mathematical Modeling of Intercellular Calcium Waves in Fibroblast Networks — •Kara Nachtnebel — Isarstr, 6, 93057 Regensburg

Inflammatory responses are essential for defending against pathogens but can result in tissue damage when not properly regulated. Resident tissue macrophages (RTMs) play a crucial role in maintaining immune homeostasis by modulating inflammatory cascades. Disruptions in these regulatory mechanisms can lead to heightened immune responses and may contribute to the development of autoimmune diseases. This study explores the role of fibroblast networks and their calcium signaling dynamics in maintaining tissue homeostasis. We aim to understand the mechanisms underlying these dynamics and predict calcium signal propagation in both healthy and pathological tissues. A mathematical model is developed to describe intracellular calcium ion diffusion and Inositol-1,4,5-triphosphate (IP3) signaling in fibroblast cells interconnected by gap junctions (GJs). This model incorporates intracellular calcium stores and IP3-sensitive receptor (IPR) dynamics, which significantly influence calcium release into the cytoplasm. IP3 generation is modeled as a function of phospholipase-C (PLC) activation, triggered either by external stimuli or by calcium, leading to calcium-induced calcium release (CICR). Our approach provides insights into how calcium signaling networks contribute to tissue homeostasis and how their dysfunction occurs in pathological conditions.

Keywords: calcium signals; fibroblast networks; immune system; IP3; intercellular calcium waves