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BP: Fachverband Biologische Physik
BP 14: Poster Session I
BP 14.24: Poster
Dienstag, 18. März 2025, 10:00–12:30, P3
Mathematical modelling of immune response on the example of psoriasis — •Nadezhda Esenkova1,2, Lukas Pöschl1,2, Gerard C. L. Wong3, and Vasily Zaburdaev1,2 — 1Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany — 2Max-Planck-Zentrum für Physik und Medizin, Erlangen, Germany — 3University of California, Los Angeles, USA
In recent years it was shown that antimicrobial peptides (AMPs) can contribute to the immune response by triggering Toll-Like Receptors (TLRs) on immune cells. Apart from natural AMPs it was suggested that proteolytic enzymes, secreted by neutrophils can digest other signaling molecules to AMP-like fragments, which can stimulate immune response and lead to disease progression. The goal of this work is to create a mathematical model of immune response by introducing this novel link of AMP-like fragments. To this aim we constructed a comprehensive signaling network of the immune response based on one of the best studied autoinflammatory diseases -- psoriasis. Taking into account the key biological pathways we reduced it to the core network model, which we investigate using theoretical dynamical systems analysis and modern machine learning methods. We aim to understand how the hypothesized mechanism of autoinflammation due to AMP-like fragments augments the disease outcomes from full resolution, to chronification and rapid exacerbation.
Keywords: psoriasis; immune; reaction; network; diffusion