Regensburg 2025 – scientific programme

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BP: Fachverband Biologische Physik

BP 17: Poster Session II

BP 17.10: Poster

Tuesday, March 18, 2025, 18:00–20:30, P4

DNA origami laden with bespoke magnetic nanocubes: A route to programmable torques at the nanoscale — Florian Rothfischer¹, Yihao Wang², Lennart Weiß¹, Christopher Pauer³, Kevin Lang³, Susanne Kempter³, Rabia Amin², Elena Eiwanger³, Jan Lipfert⁴, Tim Liedl³, Friedrich C Simmel¹, Joe Tavacoli³, and •Aidin Lak² — ¹Physics Department E14, Technical University Munich — ²Institute for Electrical Measurement Science and Fundamental Electrical Engineering and Laboratory for Emerging Nanometrology (LENA), TU Braunschweig — ³Faculty of Physics and Center for NanoScience, LMU Munich — ⁴Institute for Physics, Augsburg University

Magnetic-field responsive actuators offer minimally-invasive and deep-tissue perturbation of cellular processes. Despite progress, the magnetic manipulation of cells at the single receptor level is still challenging; magnetic nanoparticles (MNPs) can only exert ~ fN forces. To achieve biologically relevant pN forces, it is necessary to assemble MNPs together in a controllable manner. This has not yet been achieved utilizing soft-synthetic templates, where control over the number, and orientation of MNPs remains a challenge. DNA origami (DNAO) can overcome this limit, specifically so for its capacity to arrange nanoparticles at high spatial resolution. Here, we demonstrate assembly of bespoke MNPs on 6 helix-bundle DNAO and show the controlled magnetic rotation of magnetic DNAOs under circulating magnetic fields of 8 mT. Our magnetic DNAOs are promising torque nanoprobes for activation of sub-cellular processes at high resolution.

Keywords: Magnetic Nanoparticles; DNA origami; Magnetic nanoactuation; Controlled assembly; cell receptor perturbation