Regensburg 2025 – scientific programme
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BP: Fachverband Biologische Physik
BP 17: Poster Session II
BP 17.13: Poster
Tuesday, March 18, 2025, 18:00–20:30, P4
Nanoscale drug delivery system aggregates controlably on graphite — •Henrik Siboni1, 2, Leonhard Grill2, and Andreas Zimmer1 — 1Pharmaceutical Technology & Biopharmacy, University of Graz, Austria — 2Single Molecule Chemistry, University of Graz, Austria
Nanoscale drug delivery systems are nanoparticles used to enhance the efficacy of drugs and their effectiveness depends on physical properties such as size, shape and aggregation behaviour. These parameters can be measured on a substrate with atomic force microscopy, but conserving the individual nanoparticles has proven challenging. In this study, we show that the substrate highly-oriented pyrolytic graphite allows for controllable imaging of single as well as aggregated protamine-oligonucleotide drug delivery systems. This approach can potentially be used to screen drug delivery systems and avoid unnecessary in vivo test.
Keywords: Atomic Force Microscopy; Drug Delivery System; Aggregation; Imaging; Self-assembly