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BP: Fachverband Biologische Physik

BP 17: Poster Session II

BP 17.13: Poster

Dienstag, 18. März 2025, 18:00–20:30, P4

Nanoscale drug delivery system aggregates controlably on graphite — •Henrik Siboni^{1, 2}, Leonhard Grill², and Andreas Zimmer¹ — ¹Pharmaceutical Technology & Biopharmacy, University of Graz, Austria — ²Single Molecule Chemistry, University of Graz, Austria

Nanoscale drug delivery systems are nanoparticles used to enhance the efficacy of drugs and their effectiveness depends on physical properties such as size, shape and aggregation behaviour. These parameters can be measured on a substrate with atomic force microscopy, but conserving the individual nanoparticles has proven challenging. In this study, we show that the substrate highly-oriented pyrolytic graphite allows for controllable imaging of single as well as aggregated protamine-oligonucleotide drug delivery systems. This approach can potentially be used to screen drug delivery systems and avoid unnecessary in vivo test.

Keywords: Atomic Force Microscopy; Drug Delivery System; Aggregation; Imaging; Self-assembly