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BP: Fachverband Biologische Physik
BP 17: Poster Session II
BP 17.14: Poster
Dienstag, 18. März 2025, 18:00–20:30, P4
Printed biometamaterials for mechanical regulation of cells — •Clara Schaefer1, Alexander Berkes2, Martin Wegener2, Natalie Munding1, and Motomu Tanaka1,3 — 1Institute of Physical Chemistry, Heidelberg University, 69120 Heidelberg, Germany — 2Institute of Applied Physics, KIT, 76131 Karlsruhe, Gemany — 3Kyoto University, Kyoto 606-8501, Japan
Ample evidence has shown that cells detect and respond to the mechanical properties of their microenvironment. Materials with non-conventional mechanical properties (mechanical metamaterials) have shown significant effects on human mesenchymal stem cells (Munding, et al. Adv. Funct. Mater. 2024). The key requirements are to make the unit cell size smaller than the cells and to make the materials deformable by cell traction forces. The anisotropic elastic properties lead to different responses in the traction force field that are distinct from those to bulk materials. To deal with multicellular systems and to follow cell migration, one of the challenges is to increase the lateral size to several hundreds of µm. To achieve this goal, we increased the printing speed by using a new multi-focus device in two-photon laser printing. This enables to fabricate even asymmetric metamaterial structures that can potentially be used to induce cell polarization.
Keywords: Metamaterials; polarization; printing