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BP: Fachverband Biologische Physik

BP 17: Poster Session II

BP 17.31: Poster

Dienstag, 18. März 2025, 18:00–20:30, P4

Intracellular mechanics in migrating cells — •Jannis Fischer, Mohammad Amin Eskandari, and Timo Betz — Third Institute of Physics, Göttingen, Germany

To fulfill their incredibly large number of different tasks, biological cells have developed mechanisms to adapt their physical properties and appearance. The proper control of these changes is crucial, as they are not only essential for healthy cells, but can also distinguish healthy from diseased cells. Important examples related to such changes in mechanical properties are cell shape variation or cell migration. It is still not clear whether the changes in these mechanical properties are due to passive or active processes. Investigating and understanding these processes is the core of this work. For this, I will analyze the behavior of migrating cells, which are induced to move alternately on patterns and within channels. To connect the observed dynamics with the underlying mechanical properties and activities I will use the new quantity of mean back relaxation (MBR). Findings in this area could provide information for the big question of whether the mechanical properties of cells can be predicted by their activity.

Keywords: Intracellular mechanics; Cell migration; Activity; Cytoskeleton; Mean Back Relaxation