Regensburg 2025 – scientific programme
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BP: Fachverband Biologische Physik
BP 17: Poster Session II
BP 17.42: Poster
Tuesday, March 18, 2025, 18:00–20:30, P4
Theoretical perspectives on controlling cells by ultrasound — •Niels Gieseler1,2,3, Falko Ziebert1,2, and Ulrich S. Schwarz1,2 — 1Institute for Theoretical Physics, Heidelberg University, Philosophenweg 19, Heidelberg 69120 Germany. — 2BioQuant, Heidelberg University, im Neuenheimer Feld 267, Heidelberg 69120 Germany — 3Max Planck Institute for Medical Research, Jahnstrasse 29, 69120 Heidelberg, Germany
Aside from the well-known use of ultrasound in medical imaging, there are many other biomedical applications of ultrasound, including enhanced bone healing, neurostimulation and sonogenetics. Different mechanisms have been implicated for these processes, including temperature changes, cavitation, radiation forces and acoustical streaming. In this work, we are interested in the interaction between ultrasound and tissue (including organoids) at the single-cell level. Combining concepts from hydrodynamics, elasticity theory and soft matter, we aim at theoretical predictions of the relative relevance of these different effects. In particular, we use the theory of viscoelasticity to predict whether intracellular streaming and organelle movement can be controlled by ultrasound.
Keywords: Acoustofluidics; Acoustic Streaming; Viscoelasitcity; Mechanotransduction; Cell mechanics