Regensburg 2025 – wissenschaftliches Programm

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BP: Fachverband Biologische Physik

BP 17: Poster Session II

BP 17.44: Poster

Dienstag, 18. März 2025, 18:00–20:30, P4

Modeling the endothelial cytoskeleton response to blood flow — •Berin Becic and Stephan Gekle — Biofluid Simulation and Modeling, University Bayreuth, Germany

As present in blood flow, it was observed that a shear flow leads to an alignment of endoethelial cells, which is connected to an alignment of its cytoskeleton. Understanding this behavior is important as its failure can lead to chronic inflammation which is one cause for the formation of artherosclerosis and other cardiovascular diseases. In order to do this we develop a three-dimensional model for the formation of the cytoskeleton based on the stress- and strain-dependency of the stress-fiber association and dissociation dynamics, as proposed by Deshpande et al (A bio-chemo-mechanical model for cell contractility , PNAS 2006). This model also offers the opportunity to study the spatially resolved formation of the cytoskeleton as observed in cells adhering to a substrate or the mechanic interactions between the cell and its nucleus.

Keywords: Cell Contractility; pulsatile flow; blood flow; endothelium; cell mechanics