Regensburg 2025 – wissenschaftliches Programm
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BP: Fachverband Biologische Physik
BP 17: Poster Session II
BP 17.6: Poster
Dienstag, 18. März 2025, 18:00–20:30, P4
Macroscopic transports in cellular aggregates driven by dipole forces — •Subhadip Chakraborti1,2 and Vasily Zaburdaev1,2 — 1Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany — 2Max-Planck-Zentrum für Physik und Medizin, Erlangen, Germany
The large-scale collective behavior of biological systems can be understood through macroscopic transport processes that emerge from the active interactions of individual components at the microscopic level. A striking example is the clustering and the associated transport slowdown observed in colonies of Neisseria gonorrhoeae bacteria, driven by active, contractile forces mediated by pili. In this study, we analytically derive the fluctuating hydrodynamics from the microscopic dynamics of a 2D model system representing an N. gonorrhoeae bacterial colony. The hydrodynamic current of cells involves two macroscopic transport coefficients: bulk diffusivity and conductivity, which generally depend on cell density and other microscopic parameters. Remarkably, our simulation results strongly support the analytical predictions of transport slowdown during the colony formation process. Beyond bacterial colonies, these findings offer insights into how contractile forces influence transport in other biological systems, such as tumor spheroids and neuronal organoids, and suggest experimental approaches for studying these phenomena.
Keywords: Active matter; Fluctuating hydrodynamics; Transport; Cellular aggregates