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BP: Fachverband Biologische Physik
BP 17: Poster Session II
BP 17.73: Poster
Dienstag, 18. März 2025, 18:00–20:30, P4
Cellular Potts Model links tissue surface tension to cell proliferation — •Kai Lennard Fastabend1, Cécile M. Bidan2, John W. C. Dunlop3, and Philip Kollmannsberger1 — 1Biomedical Physics, Heinrich Heine University Düsseldorf, 40225 Düsseldorf, Germany — 2Max Planck Institute of Colloids and Interfaces, Dept. of Biomaterials, Golm, Germany — 3Paris Lodron University, Salzburg, Austria
The shape and growth kinetics of tissue depend not only on biochemical factors but also on the geometry of the extracellular environment. Cellular Potts Model simulations of tissue growth on different substrate geometries are a promising approach to investigate the role of adhesion forces, cell elasticity and tissue surface tension in the formation and organisation of tissue. To investigate how tension-dependent cell proliferation in tissues can explain the observed link between scaffold geometry and tissue growth kinetics, we implemented a growth rule based on the stretching of cells in CompuCell3D. Systematic parameter scans reveal the role of cell-substrate adhesion as the driving factor for monolayer formation, while cortical contractility introduces a surface tension to the tissue. The minimization of the macroscopic tissue surface leads to bulk tissue growth beyond the monolayer depending on the underlying substrate geometry. Our results highlight how cellular contractility and adhesion, together with geometric boundary conditions can determine the macroscopic growth patterns of tissues, independent of soluble growth factors.
Keywords: Cellular Potts Model; tissue growth; surface tension