Regensburg 2025 – scientific programme
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BP: Fachverband Biologische Physik
BP 17: Poster Session II
BP 17.79: Poster
Tuesday, March 18, 2025, 18:00–20:30, P4
AFM imaging of epithelial basement membrane with and without molecular perturbations — •Karla Yanin Guerra Santillan1, Christian Dahmann2, and Elisabeth Fischer-Friedrich1 — 1Cluster of Excellence Physics of Life, Technische Universit\"at Dresden, Dresden, Germany — 2School of Science, Technische Universit\"at Dresden, Dresden, Germany
Understanding the precise regulation of growth and form is fundamental to the healthy development of all organisms. The basement membrane is a specialized sheet of extracellular matrix that forms at the basal face of epithelial tissues. This biopolymer network plays a major role in structural support, proliferation regulation and biochemical signalling. Here, we present data of high-resolution images of the basement membrane in developing wing discs of the fruit fly Drosophila melanogaster using atomic force microscopy. We find that depending on the developmental stage, micron-sized ripple patterns of different amplitude are present on the surface of the basement membrane that depend on the presence of individual ECM proteins.
Keywords: basement membrane; atomic force microscopy; self-organized pattern formation; extracellular matrix