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BP: Fachverband Biologische Physik
BP 17: Poster Session II
BP 17.82: Poster
Dienstag, 18. März 2025, 18:00–20:30, P4
Epithelial Tissue Response Under Solid Shear Stress — •Narmin Abasova1, Annemarie Wirth1, Kevin Hoellring1, Rudolf Merkel2, and Ana-Sunčana Smith1,3 — 1PULS Group, Institute for Theoretical Physics, FAU Erlangen- Nurnberg (IZNF) — 2Institute for Biological Information Processes (IBI), Forschungszentrum, 52428 Jülich, Germany — 3Group of Computational Life Sciences, Division of Physical Chemistry, Ruder Bošković Institute, 10000 Zagreb, Croatia
Epithelial cells are subjected to a diverse range of mechanical stresses in the human body, from the dynamic forces generated during physical activity to the rhythmic pulsations of blood flow. To better understand the mechanobiological processes due to various stress types, it is essential to investigate how they influence cellular responses and tissue functionality. Among the different forms of mechanical stress, solid shear stress transmitted through the extracellular matrix (ECM) remains a relatively underexplored side of tissue mechanics. Our research addresses this gap by utilising a custom-designed device that applies controlled shear stress to the substrate supporting epithelial cell cultures. By subjecting targeted cell clusters to solid shear stress, we observe and document the tissue's behavior under a microscope. This study examines key aspects of cellular response, including stress relaxation, proliferation, morphological alterations and topological changes at cell membranes, where neighboring cells exchange positions. Using stress-generating devices in this context allows us to better understand how distinct stress types influence tissue behavior.
Keywords: Epithelial cells; Shear stress; Tissue mechanics; Stress relaxation; Mechanobiology