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BP: Fachverband Biologische Physik

BP 18: Tissue Mechanics

BP 18.2: Vortrag

Mittwoch, 19. März 2025, 10:00–10:15, H44

Regulation of Homeostatic Tissue Composition and Self- Organization via Pressure-mediated Cell Cycle Control in Stem Cell-Derived Epithelial Tissues — •Johannes Krämer¹, Edouard Hannezo², Gerhard Gompper¹, and Jens Elgeti¹ — ¹Forschungszentrum Jülich, Institute for Advanced Simulations — ²Institute of Science and Technology Austria

Tissue homeostasis relies on a precise balance between cellular proliferation and differentiation, with spatial cell distribution playing a critical role in effective replenishment. The mechanisms governing self-renewing cell types, including their proliferation rates, mechanical interactions, and spatial organization, remain incompletely understood. Here, we present a study of epithelial tissue dynamics using a descendant lineage model derived from slow-cycling, self-renewing stem cells. Through mean-field analysis, we establish conditions for cell cycle parameters that maintain a well-defined tissue configuration and demonstrate the influence of mechanical regulation on division control. To further explore spatio-temporal properties, we implement the lineage model in an agent-based computational framework, incorporating cell-cell mechanical interactions. Our findings reveal a regime in which stem cells exhibit long-range order, forming small, localized niche-like clusters with slow diffusion. These insights offer a novel perspective on the interplay between proliferation, differentiation, and the role of mechanical interactions on the spatial organization of cells, advancing our understanding of tissue homeostasis.

Keywords: stem cells; computational modeling