Regensburg 2025 – wissenschaftliches Programm

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BP: Fachverband Biologische Physik

BP 19: Membranes and Vesicles II

BP 19.7: Vortrag

Mittwoch, 19. März 2025, 11:00–11:15, H46

Modeling endosomal membrane budding patterns — •Felix Frey and Andela Saric — Institute of Science and Technology Austria, Klosterneuburg, Austria

Lipid membranes define cells and structure their interior. Endosomes, which are organelles that host molecular cargo sorting processes, are enclosed by flexible membranes from which small vesicles continuously pinch off. The reshaping of the endosomal membrane is mediated by filamentous proteins of the ESCRT-III family. Strikingly, in endosomes of flowering plant cells, arrays of concatenated membrane vesicles can form, which are connected either in parallel or in series with the membrane base. Here we combine coarse-grained molecular dynamics simulations and continuum theory with electron tomography to study the budding patterns at plant endosomal membranes [1]. We find that changes in ESCRT-III filament properties, such as curvature and membrane binding energy, determine the formation pathways and shapes of the emerging vesicle networks.

[1] E. Weiner*, E. Berryman*, F. Frey*, A. González Solís* et al., Proc. Natl. Acad. Sci. U.S.A. 121.44 (2024): e2409407121. *Equal contributions.

Keywords: Membrane biophysics; Computational biophysics; Multivesicular endosomes; Coarse-grained molecular dynamics simulations; Continuum theory