Regensburg 2025 – wissenschaftliches Programm
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BP: Fachverband Biologische Physik
BP 19: Membranes and Vesicles II
BP 19.8: Hauptvortrag
Mittwoch, 19. März 2025, 11:30–12:00, H46
Rolling vesicles: From confined rotational flows to surface-enabled motion — •Laura R. Arriaga1, Paula Magrinya1, Pablo Palacios1, Pablo Llombart1, Rafael Delgado-Buscalioni1, Alfredo Alexander-Katz2, and Juan L. Aragones1 — 1Department of Theoretical Condensed Matter Physics, Condensed Matter Physics Center (IFIMAC) and Instituto Nicolás Cabrera, Universidad Autonoma de Madrid, 28049, Madrid, Spain — 2Department of Materials Science and Engineering, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA
Friction forces are essential for cell movement, yet they also trigger numerous active cellular responses, complicating their measurement in vivo. In this talk, we will introduce a synthetic model designed to measure friction forces between biomimetic membranes and substrates. The model consists of a vesicle with precisely controlled properties, fabricated via microfluidics, encapsulating a single ferromagnetic particle that is magnetically driven to rotate. The rotation of the particle generates a confined rotational flow, setting the vesicle membrane into motion. By adjusting the magnetic field frequency and vesicle size, the rotation frequency of the vesicle can be finely controlled, resulting in a rolling vesicle that functions as an effective tribological tool. At low frequencies, molecular contact between the membrane and substrate dominates frictional interactions, providing a measurement of the contact friction coefficient. Adjusting membrane fluidity within this model will enable the study of frictional processes in more complex biomimetic systems.
Keywords: vesicles; microfluidics; friction; hydrodynamics; rolling