Regensburg 2025 – wissenschaftliches Programm
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BP: Fachverband Biologische Physik
BP 22: Bioimaging
BP 22.8: Vortrag
Mittwoch, 19. März 2025, 17:15–17:30, H46
Grating Based X-ray Phase Contrast CT with Laboratory Setups — •Luka Gaetani1,2, Josef Scholz1,2, Lorenz Birnbacher2,3, and Julia Herzen1,2 — 1Research Group Biomedical Imaging Physics, Department of Physics, TUM School of Natural Sciences, Technical University of Munich, 85748 Garching, Germany — 2Chair of Biomedical Physics — 3Institute for Diagnostic and Interventional Radiology, TUM Klinikum rechts der Isar, 81675 München, Germany
Grating-based X-ray Phase Contrast Computed Tomography (CT) represents a significant advancement in imaging, offering enhanced sensitivity to soft tissues and low-density materials by capturing phase information complementary to absorption contrast. This technique utilizes a series of optical gratings to measure phase shifts introduced by the sample, enabling the reconstruction of high-resolution phase contrast images. Laboratory-based implementations of this method, facilitated by compact X-ray sources and precise grating alignment, have extended its accessibility and applicability to diverse fields. However, optimizing these setups necessitates addressing challenges such as coherence management, efficient data acquisition, and advanced reconstruction algorithms to maximize their performance in non-synchrotron environments. This presentation will demonstrate how a grating-based interferometer enables the quantitative determination of electron density, a physical property of the sample, by accurately correlating the sample's influence on the gray values in the recorded X-ray images.
Keywords: X-Ray Phase Contrast; Dark Field Imaging; Quantified CT Imaging; Grating Based Interferometry