Regensburg 2025 – wissenschaftliches Programm
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BP: Fachverband Biologische Physik
BP 25: Cell Mechanics II
BP 25.10: Vortrag
Donnerstag, 20. März 2025, 12:15–12:30, H44
Aggregation and disaggregation of red blood cells — •Kirill Korneev1, Nicolas Moreno2, Thomas John1, Christian Wagner1, and Dmitry Fedosov3 — 1Experimental Physics, Saarland University — 2Basque Center for Applied Mathematics, Bilbao Spain — 3Theoretical Physics of Living Matter, Forschungszentrum Jülich
Laser tweezers (LT) are devices for manipulating, trapping and force measurement on particles into optical traps. Red blood cells (RBCs) are the majority of blood cells. Those cells are very deformable and show spontaneously forming complex structures at rest state, due to aggregation. The mechanisms of RBCs aggregation are not fully understood, however there are currently two main hypotheses that can explain it: the bridging model based on mobile and immobile bonds, and the depletion layer model. In this work, experimental values of the RBCs disaggregation force were obtained by stretching RBC aggregates. We will show, that the mechanism of RBCs disaggregation involves these two hypotheses. We will also show that the bridging model with mobile bonds reproduces well the corresponding experimental data, offering insights into the interplay between bridging and depletion interactions and providing a framework for studying similar interactions between other biological cells.
N. Moreno, et al., Aggregation and disaggregation of red blood cells: depletion versus bridging, bioRxiv 2024.11.20.624311 (2024)
Keywords: red blood cells; laser tweezers; aggregation; depletion