Regensburg 2025 – scientific programme
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BP: Fachverband Biologische Physik
BP 25: Cell Mechanics II
BP 25.5: Talk
Thursday, March 20, 2025, 10:45–11:00, H44
Towards a better understanding of the cytokinetic contractile ring — •Francine Kolley-Köchel1 and Sebastian Aland1,2 — 1Faculty of Mathematics and Informatics, TU Freiberg, 09599 Freiberg, Germany — 2Faculty of Informatics/Mathematics, HTW Dresden, 01069 Dresden, Germany
The dynamics of viscoelastic surfaces plays an important role in biological systems. One prominent example is the actin cortex, with elastic properties on short time scales and viscous on long time scale. Numerical simulations of such a system can provide a better understanding of the real biological system. Here we present a novel monolithic model of viscoelastic surfaces within a dominant surface rheology, capturing both, shear and dilational dynamics. We demonstrate that these full three dimensional simulations are numerically stable for low and high surface viscosities and show spontaneous pattern formation, induced by active stress regulation. We discuss how this model can guide future work towards a betters understanding of complex viscoelastic surface dynamics and the formation of the cytokinetic contractile ring.
Keywords: Contractile ring; Viscoelasticity; Cortex