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BP: Fachverband Biologische Physik

BP 26: Synthetic life-like systems and Origins of Life

BP 26.7: Vortrag

Donnerstag, 20. März 2025, 11:30–11:45, H46

Prebiotic RNA Replication through Templated Ligation by Humidity and pH Cycles — •Felix T. Dänekamp and Dieter Braun — Systems Biophysics LMU, Munich, Germany

To replicate long RNA strands, templated ligation from 2',3'-cyclic phosphate RNA is a promising pathway. Preliminary screenings suggest that through tuning of monovalent salt content and through adding Lysine or other amino acids to the solution, no additional catalysts are required to attain yields of 50% ligation product in one day. Cycling physical conditions such as pH and salt/RNA concentration likely solves the strand inhibition problem. This opens up the possibility of prebiotic ligation chain reactions and thus open-ended evolution from short RNA strands.

Keywords: origins of life; RNA; humidity cycle; ligation chain reaction; prebiotic replication