Regensburg 2025 – scientific programme

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BP: Fachverband Biologische Physik

BP 3: Computational Biophysics I

BP 3.9: Talk

Monday, March 17, 2025, 12:00–12:15, H44

Hepatitis C Virus Infection Alters NK Cell Receptor Expression: A High-Dimensional Analysis — •Andrea Schneider — Heirich-Heine Universität Düsseldorf

Hepatitis C virus (HCV) infection influences the expression of receptors on natural killer (NK) cells, a crucial component of the innate immune system. Using fluorescent markers for flow cytometry measurements, receptor expression can be analyzed to identify differences between healthy individuals, recovered patients, and those with chronic infections. Due to the possibility of using many markers simultaneously in one measurement, algorithms for dimension reduction are necessary for the evaluation of flow cytometry data. These findings could provide a potential starting point for novel therapeutic approaches. A key focus of the talk is the application of t-SNE, a dimensionality reduction algorithm that visualizes high-dimensional data in two-dimensional scatterplots while preserving high-dimensional clustering. The analysis offers valuable insights into the cellular differences among the three patient groups and opens new perspectives for immunological research.

Keywords: NK-cells; t-SNE; Clustering; Dimension Reduction; Flow cytometry