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BP: Fachverband Biologische Physik
BP 4: Bacterial Biophysics
BP 4.6: Vortrag
Montag, 17. März 2025, 11:00–11:15, H46
Slower prior growth in E. coli confers a competitive advantage under carbon starvation — •Zara Gough1, Hamid Seyed Allaei1, Severin Schink2, Elena Biselli1, Sophie Brameyer3, and Ulrich Gerland1 — 1Physics of Complex Biosystems, Physics Department, Technical University of Munich, 85748 Garching, Germany — 2Department of Systems Biology, Harvard Medical School, 200 Longwood Ave, Boston, MA 02115, USA — 3Microbiology, Faculty of Biology, Ludwig Maximilians University Munich, Martinsried, Germany
Bacteria spend much of their life cycle under nutrient limitation, competing for resources to survive. Recent research has quantitatively characterized the carbon starvation kinetics of E. coli in monoculture using two experimentally measurable parameters: the maintenance rate and the recycling yield. Building on this framework, we show that these same parameters can predict fitness changes when cultures with distinct prior growth rates are subjected to starvation in co-culture. We introduce an additional model that explores the interaction between intracellular energy reserves and extracellular medium energy during co-culture starvation, and accounts for different uptake rates resulting from prior growth rate. Using a bottom-up approach to modelling that is derived directly from bacterial physiology, our work extends the quantitative understanding of population dynamics in E. coli.
Keywords: Bacterial physiology; Bacterial fitness; Population dynamics; Carbon starvation; Metabolic adaptation