Regensburg 2025 – scientific programme

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BP: Fachverband Biologische Physik

BP 8: Biomaterials, Biopolymers and Bioinspired Functional Materials I (joint session BP/CPP)

BP 8.3: Talk

Monday, March 17, 2025, 15:30–15:45, H46

Superselective multivalent client recruitment in biomolecular condensates — •Xiuyang Xia and Erwin Frey — Ludwig-Maximilians-Universität München

Biomolecular condensates (BMCs) are membraneless organelles formed via liquid-liquid phase separation, playing a crucial role in organizing cellular functions by selectively concentrating specific molecules. In this talk, I will present a new theoretical framework that models multivalent client recruitment in valence-limited, multicomponent systems like BMCs. We uncover how enthalpic and entropic factors interplay under valence constraints to enable switch-like recruitment and precise compositional regulation.

This work advances our understanding of the principles governing BMC composition and highlights the broader significance of multivalency in biological systems, offering insights into cellular organization and potential therapeutic applications.

Keywords: Biomolecular condensates; Coarse-grained modeling; Multivalent interaction; Superselectivity