Regensburg 2025 – wissenschaftliches Programm
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CPP: Fachverband Chemische Physik und Polymerphysik
CPP 15: Poster Session I
CPP 15.18: Poster
Montag, 17. März 2025, 19:00–21:00, P4
Programming fibril alignment and mechanical response in electron beam-modified collagen type I fibers — •Friedrich Schütte1,2, Anastassiya Bublikova1,2, and Stefan G. Mayr1,2 — 1Division of Surface Physics, Department of Physics and Earth System Sciences, University of Leipzig, Linnéstr. 5, 04103 Leipzig — 2Leibniz Institute of Surface Engineering (IOM), Permoserstr. 15, 04318 Leipzig, Germany
Modifying collagenous systems for tendon and tissue replacements in a controlled manner to produce biomimetic implants has a high potential for future biomedical applications. As a polymeric biomaterial, abundant in human bodies and influencing cellular morphology, collagen type I provides structural integrity and strength to tissues. However, applications are limited because even in crosslinked cases, the biomechanical properties of collagen networks can differ by several orders of magnitude in terms of both elasticity and load capacity. The widely used crosslinker glutaraldehyde has been the subject of controversy due to cytotoxic effects. In contrast, electron-beam-treatment allows reagent free control over a rapid and sterilizing crosslinking method in a non-cytotoxical biomimetic manner, resulting in improved mechanical properties due to high penetration depth and sufficiently high irradiation-induced doses. Subsequently, the modification of collagen type I fibers by energetic electron-beam-treatment during prestrain induced alignment of the inner filaments is shown to achieve and imprint network anisotropies resulting in mechanical properties with Young's moduli bridging orders of magnitude from a kPa range to a MPa range.
Keywords: Collagen Fiber; Electron Beam Cross-Linking; Tensile Testing; ESEM