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CPP: Fachverband Chemische Physik und Polymerphysik

CPP 18: Biomaterials, Biopolymers and Bioinspired Functional Materials II (joint session CPP/BP)

CPP 18.4: Vortrag

Dienstag, 18. März 2025, 10:30–10:45, H46

Enhancing drug release at interfaces with photoresponsive surfactant-polyelectrolyte mixtures — •Ipsita Pani, Michael Hardt, and Björn Braunschweig — Institute of Physical Chemistry, Center for Soft Nanoscience (SoN), University of Münster, Corrensstraße 28-30, Münster 48149, Germany

Using micellar nanocarriers of a photoresponsive arylazopyrazole (AAP) surfactant, we have recently demonstrated the drug release at air-water interface.[1] In this work, we use a biopolymer poly-L-lysine (PLL) to form surfactant-polyelectrolyte mixtures to enhance the drug release of a chemotherapeutic drug doxorubicin. We observe a strong binding between the negatively charged AAP and the positively charged PLL at equimolar ratio. The information from UV-visible spectroscopy, light scattering studies, surface tensiometry and SFG spectroscopy has been utilized to identify the concentration of PLL at which the light-induced drug release is enhanced at the interface. We found that at higher PLL:AAP ratio, the complexes have low net charge and colloidal stability and the release of Dox from the bulk solution to the air-water interface is not observed. However, at lower PLL:AAP ratio, when the system is colloidally stable with a net negative charge, the drug release to the air-water interface is significantly enhanced. Further, the kinetics of drug release to the interface is faster in presence of PLL-AAP mixtures in comparison to pure AAP micelles. Reference : [1] Pani et al. Chem. Sci., 2024, 15, 18865-18871.

Keywords: Responsive interfaces; photoswitches; biopolymer; Sum Frequency Generation Spectroscopy