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CPP: Fachverband Chemische Physik und Polymerphysik
CPP 32: Poster Session II
CPP 32.14: Poster
Donnerstag, 20. März 2025, 09:30–12:00, P3
Highly oxidized Graphene Oxide as a Drug Delivery platform: Functional Group Interactions and Controlled Release Mechanisms — •Codrut Costinas1, Liviu Cosmin Cotet2, Monica Baia1, Klara Magyari3, and Lucian Baia1 — 1Faculty of Physics, Babes-Bolyai University, Cluj-Napoca, Romania — 2Faculty of Chemistry and Chemical Engineering, Babes-Bolyai University, Cluj-Napoca, Romania — 3Interdisciplinary Research Institute on Bio-Nano-Sciences, Babes-Bolyai University, Cluj-Napoca, Romania
Graphene oxide (GO) presents a promising platform for drug delivery, given its versatile surface chemistry and high surface area that enable effective drug loading and controlled release. Our study investigates the capabilities of an in-house produced, highly oxidized GO as a carrier by examining its interactions with two model compounds: methylene blue and methyl orange, as well as two drugs: doxorubicin and gentamicin sulfate. Through spectroscopic investigations (UV-VIS, FT-IR, and Raman), potentiometric titrations, and drug loading and release experiments we successfully identify the functional groups and bond types involved in drug-GO interactions in different pH media, most notably hydrogen bonding, electrostatic interactions, and π-π stacking. Furthermore, by taking into consideration the pKa values between GO acidic groups and the drugs ionizable groups, we can estimate both loading and pH-responsive release behavior in simulated physiological pH conditions. These findings highlight the flexibility of GO as a drug carrier, supporting its application in the development of customizable drug delivery systems for various therapeutic needs.
Keywords: Graphene oxide; Drug loading mechanisms; Surface characteristics