Regensburg 2025 – wissenschaftliches Programm
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CPP: Fachverband Chemische Physik und Polymerphysik
CPP 9: Biomaterials and Biopolymers (joint session BP/CPP)
CPP 9.4: Vortrag
Montag, 17. März 2025, 15:45–16:00, H46
What is the structure of a biomolecular condensate? — •Charlotta Lorenz1,2, Teagan Bate1, Takumi Matsuzawa1, Kaarthik Varma1, Sully Bailey-Darland1, George Wang1, Dana Matthias1, Harsha Koganti2, Nicola Galvanetto2, Matti Valdimarsson2, Aleksander Rebane3, Etienne Jambon-Puillet4, Ben Schuler2, and Eric R. Dufresne1 — 1Cornell University, Ithaca, NY, USA — 2University of Zurich, Zurich, Switzerland — 3New York University Abu Dhabi, Abu Dhabi, United Arab Emirates — 4École Polytechnique Paris, Paris, France
Biomolecular condensates are important for a variety of cellular functions, such as biochemical regulation, structural organization, and RNA metabolism. While the properties and physiology of these condensates depend on their structure, this important aspect has received little experimental consideration. On the other hand, recent simulations of disordered proteins with interactions based on the sticker-and-spacer suggest fascinating structures in the bulk and surface of condensates. We aim to reveal the structure of biomolecular condensates using X-ray scattering. Here, we will present results for a simple model system and apply our approach to the structure of condensates made of disordered proteins. We particularly consider the change in condensate structure due to small molecules.
Keywords: biomolecular condensates; small-angle X-ray scattering; SAXS; phase separation