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DY: Fachverband Dynamik und Statistische Physik
DY 25: Statistical Physics of Biological Systems I (joint session BP/DY)
DY 25.3: Vortrag
Mittwoch, 19. März 2025, 15:30–15:45, H44
Reconciling conflicting selection pressures in the plant collaborative non-self recognition self-incompatibility system — Amit Jangid1, Keren Erez1, Ohad-Noy Feldheim2, and •Tamar Friedlander1 — 1Faculty of Agriculture, food and environment, The Hebrew University of Jerusalem, Rehovot, Israel — 2Einstein Institute for Mathematics, The Hebrew University of Jerusalem, Jerusalem, Israel
Complex biological systems should often reconcile conflicting selection pressures. Specifically, in systems relying on molecular recognition, molecules should recognize particular partners, but avoid others. Here we study how such selection pressures shape the evolution of the self-incompatibility system in plants. This system inhibits self-fertilization using specific molecular recognition between proteins, expressed in the plant female and male reproductive organs. We study the impact of these opposing selection pressures on the amino acid frequencies in these proteins' recognition domain. We construct a theoretical framework enabling promiscuous recognition between proteins and multiple partners each, as found empirically, and employ stochastic simulations. We find asymmetric responses to selection affecting mostly the female, but not the male protein composition. Using large deviations theory, we well-approximate the simulated frequencies and find agreement with genomic data. Our work offers a general theoretical framework to study the impact of multiple selection pressures, applicable to additional biological systems.
Keywords: maximum entropy; evolutionary theory; genotype-phenotype mapping; protein-protein interactions; large deviations theory