Regensburg 2025 – wissenschaftliches Programm
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O: Fachverband Oberflächenphysik
O 91: Focus Session Chemical Imaging for the Elucidation of Molecular Structure I (joint session O/BP)
O 91.2: Hauptvortrag
Donnerstag, 20. März 2025, 15:30–16:00, H24
Coherent Raman Imaging — •Michael Schmitt1 and Juergen Popp1,2 — 1Institute of Physical Chemistry and Abbe Center of Photonics, Friedrich-Schiller-University Jena, Helmholtzweg 4, 07743 Jena, Germany — 2Leibniz Institute of Photonic Technology, Member of Leibniz Health Technologies, Albert-Einstein-Straße 9, 07745 Jena, Germany
Raman-based technologies have profoundly impacted life sciences and biomedical research. Despite their unmatched molecular specificity, traditional Raman spectroscopy suffers from limited sensitivity, making it less suitable for rapid imaging. This limitation is addressed by coherent Raman scattering (CRS) microscopy, primarily through coherent anti-Stokes Raman scattering (CARS) and stimulated Raman scattering (SRS). This talk examines the potential of CARS and SRS imaging for biological and biomedical analysis, offering detailed insights into the molecular composition of biomedical specimens, such as cells or tissue. The presentation will focus on the applications of these techniques in molecular and functional diagnostics in the fields of medicine and life sciences. Furthermore, recent developments in translating CRS into compact, clinically viable systems, such as handheld probes, will be presented, focusing on intraoperative tumour diagnostics for early detection and improved improved therapeutic outcomes.
Acknowledgement: Financial support of the EU, the *Thüringer Ministerium für Wirtschaft, Wissenschaft und Digitale Gesellschaft*, the *Thüringer Aufbaubank*, the BMBF, the DFG, and the Carl Zeiss Stiftung is acknowledged.
Keywords: Raman; CARS; SRS; Biomedical analysis; Molecular imaging