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SOE: Fachverband Physik sozio-ökonomischer Systeme
SOE 3: Poster
SOE 3.10: Poster
Montag, 17. März 2025, 17:30–19:30, P4
Multisensory processing in superior colliculus and primary sensory cortex — •Daniel Gerber1, Peter Severin Graff1,2, Björn Kampa2, and Simon Musall1,2,3 — 1Institute of Biological Information Processing (IBI-3), Forschungszentrum Jülich, Jülich, Germany — 2Department of Systems Neurophysiology, Institute for Zoology, RWTH Aachen University, Aachen, Germany — 3Institute of Experimental Epileptology and Cognition Research, University of Bonn Medical Center, Bonn, Germany
The superior colliculus (SC) plays a crucial role in integrating multisensory stimuli and is associated with various cognitive functions, such as decision-making. It receives inputs from different sensory modalities, either directly from sensory organs or from primary sensory regions in the cortex. However, the distinctions between multisensory integration in the SC and the cortex remain unclear. To study the physiological underpinning of multisensory integration in these areas, awake mice were exposed to visual, tactile, and multisensory stimuli, while neural activity was recorded in primary visual cortex (V1), primary somatosensory cortex (S1) and the SC simultaneously using high-density Neuropixels electrodes. To investigate the influence of the cortical projection to the SC, in some trials V1 and/or S1 were optogenetically inhibited. A generalized linear model is used to analyse the spiking activity. We present that SC is modulated by cortical input but does not strongly rely on it. We also present the change in neural activity over the course of repeated stimulus.
Keywords: Multisensory; GLM; Electrophysiology